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Background: Antiretroviral chemoprophylaxis before exposure is a promising approach for the prevention of human immunodeficiency virus HIV acquisition. Methods: We randomly ased HIV-seronegative men or transgender women who have sex with men to receive a combination of two oral antiretroviral drugs, emtricitabine and tenofovir disoproxil fumarate FTC-TDFor placebo once daily. All subjects received HIV testing, risk-reduction counseling, condoms, and management of sexually transmitted infections.

: The study subjects were followed for person-years median, 1. Detectable blood levels strongly correlated with the prophylactic effect. Figure 2. Figure 4. Hailey gates sexy enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.

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Send even when there aren't any new. Optional text in :. Save Cancel. Create a file for external citation management software Create file Cancel. of items displayed: 5 10 15 20 50 Create RSS Cancel. RSS Link Copy. Full text links Cite Display options Display options. Abstract Background: Antiretroviral chemoprophylaxis before exposure is a promising approach for the prevention of human immunodeficiency virus HIV acquisition. Figures Figure 1. Enrollment and Outcomes The most…. Figure 1. Enrollment and Outcomes The most common laboratory abnormalities that led to exclusion were….

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The most common laboratory abnormalities that led to exclusion were elevations in hepatic aminotransferase levels, hyperbilirubinemia, and renal insufficiency. A total of 18 enrollees 0. All enrolled subjects, including those who were subsequently found to be ineligible, were followed for HIV infection and safety.

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Quarterly-visit attendance is shown. Kaplan—Meier Estimates of Time to…. The cumulative probability of HIV acquisition is shown for the two study groups. The inset graph shows a more detailed version of the overall graph up to a probability of 0. Figure 3. P values for the intention-to-treat analysis and the modified intention-to-treat analysis apply to the hypothesis of any evidence of efficacy; P values for other comparisons refer to the hypothesis that efficacy differed between the two strata.

Levels of Study-Drug Components in…. The horizontal lines in each panel indicate medians. See this image and copyright information in PMC. Comment in Oral preexposure prophylaxis for HIV--another arrow in the quiver? Michael NL. N Engl J Med. Epub Nov PMID: No abstract available. Preexposure chemoprophylaxis for HIV prevention.

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Pittrof R, et al. Underhill K. Pimpinella G, Malgarini RB. Pimpinella G, et al. Sellier PO, et al. Lee DH, Vielemeyer O. Lee DH, et al. ACP Journal Club. Daily emtricitabine plus tenofovir disoproxil fumarate reduced risk for HIV infection in men who have sex with men. Kalil AC. Ann Intern Med. Oral antiretroviral pre-exposure prophylaxis reduces the risk of HIV acquisition among men who have sex with men. Boily MC, et al. Evid Based Med.

Epub May No abstract available. Wintenberger C. Med Mal Infect. PMID: French. Berger RE. J Urol. Similar articles Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. Thigpen MC, et al.

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Epub Jul Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. Baeten JM, et al. Clinical Trial.

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Daily oral tenofovir and emtricitabine-tenofovir preexposure prophylaxis reduces herpes simplex virus type 2 acquisition among heterosexual HIVuninfected men and women: a subgroup analysis of a randomized trial. Celum C, et al. Okwundu CI, et al. Cochrane Database Syst Rev. PMID: Review.

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Plosker GL. See all similar articles. Weiss KM, et al.

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